Royal Marsden NHS Foundation Trust

This implementation pilot study of whole body-MRI in patients with Li-Fraumeni syndrome, will explore the feasibility and added value of addition of this routinely available, non-ionising radiation scan to standard of care for LFS.

During the study, patient will undergo an annual WB-MRI, with the expectation that some will have early-stage, curable cancers identified. This study will present a proof of principle of the use of WB-MRI screening in specific patient cohorts and provide an exemplar of ‘targeted screening’. If successful, it would enable us to establish WB-MRI as a standard of care in adult LFS through further cost-effectiveness assessment providing valuable evidence of the importance of this intervention to NHS Commissioning bodies.