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Stream is redefining the sensitivity of lateral flow assays by replacing the traditional labels normally used, with ultra-bright (sensitive), fluorescent Conjugated Polymer Nanoparticles (CPNs), and by adopting a different approach in the development of a point-of-care reader. 

Stream is redefining lateral flow assays by significantly enhancing the key technologies involved.  By replacing the traditional labels normally used in lateral flow (ie gold nanoparticles or europium chelates) with intensely fluorescent and sensitive fluorescent Conjugated Polymer Nanoparticles (CPNs), and by adopting a different approach in the development of a reader, Stream aims to deliver lab sensitivity in a point-of-care test for troponin.  CPNs are functionalised nanoparticles with extremely high extinction coefficients and are therefore incredibly sensitive in low level detection.  To further enhance capability, rather than using fluorescent intensity to quantify detection as other readers do, Streams reader is based on a handheld fluorometer that captures images of the particles and then quantification is determined by an algorithm.   

[embed]https://sbrihealthcare.co.uk/wp-content/uploads/2021/03/Stream-Bio-SBRI-VIDEO-1.mp4[/embed]

eTriage is a digital triage solution for urgent and emergency care departments.

Developed by NHS emergency doctors and nurses, eTriage allows patients to check-in and be triaged upon arrival to an urgent and emergency care service through a series of tablets installed at the front of the department. Patients share their history by answering a series of clinical questions, which are reviewed by a triage or streaming nurse. Patients are then prioritised by clinical need or redirected to other healthcare professionals if they are low-priority. The platform reduces waiting times and crowding in waiting rooms while improving patient flow through the emergency department, ensuring patients receive the right care, first time.

This project is seeking to test whether non-urgent patients can effectively and safely be rerouted away from EDs to other more appropriate services in an automated way, through the use of eTriage.

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RAIQC is a clinical simulation platform for medical image interpretation. It will be used to train emergency department staff to enable faster diagnosis and treatment within ED leading to improved patient flow and outcomes.

Report and Image Quality Control (RAIQC) is a clinical simulation platform developed by radiologists with a combined experience of over 50 years. It mimics real-word practice and allows users to be taught and assessed for different imaging modalities ranging from X-rays to CT or MRI scans. Users interact with real-life cases, click on any abnormality and provide a diagnosis. They are provided feedback about their accuracy and speed, as well as an anonymous comparison with their peers.

The platform is accessible from anywhere through a web-browser and hosts realworld diagnostic quality scans along with interactive teaching content such as slideshows, video lectures and case-based discussions curated by expert radiologists.

[embed]https://sbrihealthcare.co.uk/wp-content/uploads/2021/03/RAIQC-Overview-1.mp4[/embed]